1/17/2024 0 Comments Fatigue after pfizer first doseIndividuals who agreed to participate in the study were asked to report daily regarding the presence and severity of any adverse reactions (local reactions such as muscle pain, erythema, skin pain, itching, and headache systemic reactions such as fever, general fatigue, chills, joint pain, and diarrhea) for a total of 8 days from the date of vaccination to day 7 after injection. ![]() The study participants were individuals aged 18 years or older who were vaccinated and who voluntarily agreed to participate in the survey. Two injections were administered intramuscularly at intervals of 21 days ± 2 days in the deltoid muscle of the upper arm using a 25G needle. According to the manufacturer's recommendations for administration of the vaccine, one frozen multidose vial was thawed at room temperature, diluted with 1.8 mL saline, and dispensed into six doses of 0.3 mL each in one 1-mL syringe per inoculation. A total of 4,503 individuals were vaccinated with the first dose, and 4,473 received a second dose. During mass COVID-19 vaccination conducted at the Kyoto Prefectural University of Medicine Hospital, we administered a survey regarding adverse reactions occurring after the first and second vaccinations, and examined the relationship between the incidence and severity of adverse reactions after COVID-19 vaccination according to sex and age.ĭuring the 4 months from March 8 to July 9, 2021, medical workers, medical students, and nursing students involved in healthcare at the Hospital of Kyoto Prefectural University of Medicine were vaccinated with the Comirnaty®. Therefore, it is important to more accurately evaluate the changes and characteristics of adverse reactions by comparing the incidence and severity of adverse reactions after each vaccination in the same vaccinee. Additionally, no reports have compared or examined data for the same vaccinee after repeated inoculations. ![]() ![]() There are few detailed reports from Japan regarding the actual symptoms and frequency of vaccine adverse effects. The prevalence and spread of COVID-19 vary greatly among ethnic groups, and the effects of and adverse reactions to the COVID-19 vaccines may also differ among ethnic groups, ,, ,, ,, ]. Because the vaccination campaign began very quickly, a lack of accurate information regarding adverse reactions is also linked to the tendency of younger people to refrain from vaccination. As a result, younger people who become infected can spread the infection and thereby constitute an important factor in perpetuating the pandemic. However, in Japan as well as other countries, vaccination tends to be avoided by young people. Large-scale vaccination is currently underway for all citizens over the age of 12 in the national plan of Japan. The target population was then expanded to people aged 65 years and over. ![]() Since February 2021, healthcare workers in Japan have been given first priority for vaccination with the Comirnaty® vaccine. The messenger RNA (mRNA) vaccines, such as the Pfizer-BioNTech COVID-19 vaccine (Comirnaty®) and Moderna mRNA-1273 COVID-19 vaccine (Spikevax®), have received emergency authorization for clinical use and have been shown to help protect high-risk groups from COVID-19 infection. The pandemic of coronavirus infection 2019 (COVID-19), which has spread to countries worldwide since the beginning of 2020, shows no sign of resolution as of the beginning of 2022.
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